Cyclopropanecarbonyl chloride → {2'-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-6-methoxy-4'-quinolin-6-yl-biphenyl-3-yl}-acetic acid ethyl ester

HRID 563761Notes

Reaction equation

HRID 563761 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[C:22]4[C:27](=[CH:28][CH:29]=3)[N:26]=[CH:25][CH:24]=[CH:23]4)=[CH:16][C:15]=2[CH2:30][NH:31][CH2:32][CH3:33])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2].[CH:35]1([C:38](Cl)=[O:39])[CH2:37][CH2:36]1>>[CH2:1]([O:3][C:4](=[O:34])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[C:22]4[C:27](=[CH:28][CH:29]=3)[N:26]=[CH:25][CH:24]=[CH:23]4)=[CH:16][C:15]=2[CH2:30][N:31]([C:38]([CH:35]2[CH2:37][CH2:36]2)=[O:39])[CH2:32][CH3:33])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 58149185(2'-Ethylaminomethyl-6-methoxy-4'-quinolin-6-yl-biphenyl-3-yl)-acetic acid ethyl ester

Product 1

HCID 58148828{2'-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-6-methoxy-4'-quinolin-6-yl-biphenyl-3-yl}-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-ethylaminomethyl-6-methoxy-4′-quinolin-6-yl-biphenyl-3-yl)-acetic acid ethyl ester and cyclopropanecarbonyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4e73d67349cc45258a2d10adc7a390d7
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

Loading…