2-Chloro-5-methyl-1,3-benzoxazole → {6-Methoxy-2'-[(5-methyl-benzooxazol-2-ylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester

HRID 563768Notes

Reaction equation

HRID 563768 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][NH2:25])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2].Cl[C:28]1[O:29][C:30]2[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][C:31]=2[N:32]=1>>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:16][C:15]=2[CH2:24][NH:25][C:28]2[O:29][C:30]3[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][C:31]=3[N:32]=2)[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 99896072-Chloro-5-methyl-1,3-benzoxazoleHCID 66606861(2'-Aminomethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester

Product 1

HCID 66608088{6-Methoxy-2'-[(5-methyl-benzooxazol-2-ylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-aminomethyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester and 2-chloro-5-methyl-benzooxazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4e027681afe2455a9a15a0d3e510254c
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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