反应详情

To (5-bromo-2-fluoro-phenyl)-methanol (1.2 g, 5.9 mmol) in DME (20 mL) was added phosphorus tribromide (0.83 mL, 8.8 mmol), and the reaction was stirred at room temperature for 6 hours. The mixture was cooled to 0° C. and adjusted to pH 6 with saturated aqueous NaHCO3. The solution was extracted with EtOAc, and the combined organic layers were dried, concentrated, and purified by silica gel chromatography to give the title compound.

1. temperatureThe mixture was cooled to 0° C.
2. extractionThe solution was extracted with EtOAc
3. customthe combined organic layers were dried
4. concentrationconcentrated
5. custompurified by silica gel chromatography