Lithium Hydroxide → HCID 66608277, compound

HRID 563802Notes

Reaction equation

HRID 563802 reaction equation
C[O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[CH:8]=[C:9]([Cl:11])[CH:10]=1.[Li+].[OH-]>O1CCOCC1>[Cl:11][C:9]1[CH:10]=[C:5]([CH2:4][C:3]([OH:26])=[O:2])[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[CH:8]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66606869HCID 66606869, compound

Product 1

HCID 66608277HCID 66608277, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(5-Chloro-2′-ethylaminomethyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester (0.010 g, 0.03 mmol) in 1,4-dioxane (2 mL) was treated with 1N aqueous LiOH (1 mL) at room temperature for 1 hour. The solution was neutralized to pH 6 and extracted with EtOAc, and the combined organic layers were concentrated and purified by preparative HPLC to give the title compound.

Workup

  1. extractionextracted with EtOAc
  2. concentrationthe combined organic layers were concentrated
  3. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-838c706fbeec4078ab1acfeba872b5a7
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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