HRID563838

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O[C@@H]2O[C@H](C(=O)OCc3ccccc3)[C@@H](O)[C@H](O)[C@H]2O)ccc1OC)C(=O)NCc1ccccc1

HCID66607701

未命名化合物

PRODUCTS

生成物

结构：CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)ccc1OC)C(=O)NCc1ccccc1

HCID54674328

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

(2S,3S,4S,5R,6S)-6-{2-[2′-(3-Benzyl-1-ethyl-ureidomethyl)-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl]-acetoxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid benzyl ester (0.2 mmol) in EtOAc was treated with 10% palladium on carbon (catalytic) and hydrogenated under a balloon of H2. The solution was filtered over a pad of Celite, and the filtrate was concentrated and purified by preparative HPLC to give the title compound.

WORKUP

后处理

filtrationThe solution was filtered over a pad of Celite
concentrationthe filtrate was concentrated
custompurified by preparative HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a475b2b39d634d0ea7951cfb4c0c71fa
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08067445B2
来源说明: uspto-grants-2011_11

反应 SMILES

C([O:8][C:9]([C@@H:11]1[C@@H:16]([OH:17])[C@H:15]([OH:18])[C@@H:14]([OH:19])[C@H:13]([O:20][C:21](=[O:55])[CH2:22][C:23]2[CH:24]=[C:25]([C:31]3[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][C:32]=3[CH2:41][N:42]([CH2:53][CH3:54])[C:43]([NH:45][CH2:46][C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)=[O:44])[C:26]([O:29][CH3:30])=[CH:27][CH:28]=2)[O:12]1)=[O:10])C1C=CC=CC=1>CCOC(C)=O.[Pd]>[CH2:46]([NH:45][C:43](=[O:44])[N:42]([CH2:41][C:32]1[CH:33]=[C:34]([C:37]([F:40])([F:39])[F:38])[CH:35]=[CH:36][C:31]=1[C:25]1[C:26]([O:29][CH3:30])=[CH:27][CH:28]=[C:23]([CH2:22][C:21]([O:20][C@@H:13]2[O:12][C@H:11]([C:9]([OH:10])=[O:8])[C@@H:16]([OH:17])[C@H:15]([OH:18])[C@H:14]2[OH:19])=[O:55])[CH:24]=1)[CH2:53][CH3:54])[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1