反应详情

温度

180 °C

5-Amino-1-methylindazole (1.56 g) in phosphoric acid (13 ml) containing water (3 ml) was heated to 180° C. for 18 hours, cooled to ambient temperature, poured into water (5 ml) then neutralised with aqueous sodium hydroxide. The solid that precipitated was filtered from solution, washed with cold water then sucked to dryness to give was hydrolysed to give 5-hydroxyl-1-methylindazole as a brown solid, (1.18 g).

1. temperaturecooled to ambient temperature
2. customThe solid that precipitated
3. filtrationwas filtered from solution
4. washwashed with cold water
5. customto give