2-Bromoethyl methyl ether → HCID 47013649, compound

HRID 563912Notes

Reaction equation

HRID 563912 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].[CH3:11][O:12][CH2:13][CH2:14]Br>C(O)C>[CH2:1]([N:3]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:14][CH2:13][O:12][CH3:11])[CH3:2]

Participants

4

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 84352N-Ethylbenzylamine

Product 1

HCID 47013649HCID 47013649, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The synthesis of BnEA was carried out in a manner similar to that of BnEO (process 2) using N-ethylbenzylamine (15 mL, 0.101 mol), bromoethyl methyl ether (0.101×1.2 mol), and ethanol (100 mL) as a solvent. BnEA (9.17 g, 47.46 mmol, yield 47%) was obtained as a yellow-orange clear liquid. [Purification was carried out by medium pressure silica gel column chromatography (n-hexane:ethyl acetate=3:2).]

Workup

  1. customThe synthesis of BnEA
  2. customBnEA (9.17 g, 47.46 mmol, yield 47%) was obtained as a yellow-orange clear liquid
  3. custom[Purification

Sources & evidence

ORD record
ord-94669348c5c6407882e017f53377ccab
Source dataset
uspto-grants-2011_11
Patent number
US08067595B2

Reaction notes

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