Sodium borohydride → 6-methoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-2,3,4,9-tetrahydro-1H-beta-carboline

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Reaction Steps

A mixture of 91 mg (0.24 mmol) 6-methoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-4,9-dihydro-3H-β-carboline and 27.7 mg (0.73 mmol) sodium borohydride in 5 mL ethanol was stirred for 2 h at room temperature. The mixture was filtered and evaporated to dryness. Trituration with ethyl acetate yielded after drying 90 mg (98%) of the title compound as light yellow solid.

Provenance & Evidence