HCID 178426700, compound → HCID 178426380, compound

HRID 564003Notes

Reaction equation

HRID 564003 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[C:7]([NH:10][C:11](=[O:22])[C:12]3[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:13]=3[CH3:21])[CH:8]=2)[NH:3][CH:2]=1>CO.[Pd]>[NH2:18][C:16]1[CH:15]=[CH:14][C:13]([CH3:21])=[C:12]([CH:17]=1)[C:11]([NH:10][C:7]1[CH:8]=[C:9]2[N:1]=[CH:2][NH:3][C:4]2=[N:5][CH:6]=1)=[O:22]

Participants

4

Reactant 1

HCID 178426700HCID 178426700, compound

Product 1

HCID 178426380HCID 178426380, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.75 g of N-(3H-Imidazo[4,5-b]pyridin-6-yl)-2-methyl-5-nitro-benzamide in 20 ml methanol were hydrogenated over 10% palladium on charcoal at room temperature and atmospheric pressure. After 3 hrs conversion was complete as judged by HPLC/MS and the catalyst was filtered off. The filtrate was evaporated and the residue was used without further purification for the next steps.

Workup

  1. filtrationthe catalyst was filtered off
  2. customThe filtrate was evaporated
  3. customthe residue was used without further purification for the next steps

Sources & evidence

ORD record
ord-c9a23aa040f04b338149e4b110f0f419
Source dataset
uspto-grants-2011_11
Patent number
US08067599B2

Reaction notes

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