Trifluoroacetic acid → HCID 67007103, compound

HRID 564005Notes

Reaction equation

HRID 564005 reaction equation
C([O:5][C:6](=[O:26])[C:7]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:9]([C:10]([NH:12][C:13]2[CH:14]=[C:15]3[CH:21]=[CH:20][NH:19][C:16]3=[N:17][CH:18]=2)=[O:11])[CH:8]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:25][C:22]1[CH:23]=[CH:24][C:7]([C:6]([OH:26])=[O:5])=[CH:8][C:9]=1[C:10]([NH:12][C:13]1[CH:14]=[C:15]2[CH:21]=[CH:20][NH:19][C:16]2=[N:17][CH:18]=1)=[O:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67007092HCID 67007092, compound

Product 1

HCID 67007103HCID 67007103, compoundYield 73.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 45 mg 4-Chloro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-isophthalamic acid tert-butyl ester in 1 ml dichloromethane were added 1 ml trifluoroacetic acid at room temperature. Stirring was continued for 2 hrs and the mixture was evaporated under vacuum to give 28 mg of the title product.

Workup

  1. customthe mixture was evaporated under vacuum

Sources & evidence

ORD record
ord-c39941045b4a4789a619e16baae06c2d
Source dataset
uspto-grants-2011_11
Patent number
US08067599B2

Reaction notes

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