HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → [4-(2-Iodo-ethyl)-phenyl]-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | [4-(2-Chloroethyl)phenyl]methanol | HCID 53929068 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | [4-(2-Iodo-ethyl)-phenyl]-methanol | HCID 18402547 | — |
Reaction Steps
To 60.0 g (352 mmol) [4-(2-chloro-ethyl)-phenyl]-MeOH (preparation 1a) in 280 mL of acetone is added 105 g (703 mmol) sodium iodide. The reaction mixture is refluxed overnight and cooled to RT. After filtration, the residue is elutriated in DCM, filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067590B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-3397e5a210bc4bd295b16f1d12b2faad |
| Source note | uspto-grants-2011_11 |