Sodium Iodide → [4-(2-Iodo-ethyl)-phenyl]-methanol

HRID 564039ノート

反応式

HRID 564039 の反応式
Cl[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[CH:6][CH:5]=1.[I-:12].[Na+]>CC(C)=O>[I:12][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 53929068[4-(2-Chloroethyl)phenyl]methanol

生成物 1

HCID 18402547[4-(2-Iodo-ethyl)-phenyl]-methanol

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To 60.0 g (352 mmol) [4-(2-chloro-ethyl)-phenyl]-MeOH (preparation 1a) in 280 mL of acetone is added 105 g (703 mmol) sodium iodide. The reaction mixture is refluxed overnight and cooled to RT. After filtration, the residue is elutriated in DCM, filtered and dried.

後処理

  1. temperatureThe reaction mixture is refluxed overnight
  2. filtrationAfter filtration
  3. filtrationfiltered
  4. customdried

出典と根拠

ORDレコード
ord-3397e5a210bc4bd295b16f1d12b2faad
出典データセット
uspto-grants-2011_11
特許番号
US08067590B2

反応ノート

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