反应详情

To 1.20 g (3.09 mmol) 4-benzyloxy-1-[2-(4-pyrrolidin-1-ylmethyl-phenyl)-ethyl]-1H-pyridin-2-one (example 1.4) in 80 mL MeOH is added 400 mg Rh/C. The reaction mixture is stirred under a hydrogen atmosphere of 3500 hPa at RT for 11 h. The catalyst is removed by filtration and the solvent is evaporated. The residue is purified by reverse HPLC chromatography (Zorbax stable bond, C18; water (0.1% formic acid)/acetonitrile 95:5 to 10:90).

1. customThe catalyst is removed by filtration
2. customthe solvent is evaporated
3. customThe residue is purified by reverse HPLC chromatography (Zorbax stable bond, C18; water (0.1% formic acid)/acetonitrile 95:5 to 10:90)