反应详情

To 500 mg (1.75 mmol) 5-benzyloxy-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (preparation 5b) in 10 mL MeOH is added 8.73 mL (8.73 mmol) 1M aqueous HCl solution and the reaction mixture is stirred overnight at RT and 10 h at reflux. MeOH is evaporated, to the residual aqueous phase is added saturated aqueous NaHCO3-solution until the solution is basic. The aqueous phase is extracted with EtOAc, the combined organic phase is washed with water, dried over MgSO4, filtered and evaporated to afford the product.

1. temperatureat reflux
2. customMeOH is evaporated, to the residual aqueous phase
3. additionis added saturated aqueous NaHCO3-solution until the solution
4. extractionThe aqueous phase is extracted with EtOAc
5. washthe combined organic phase is washed with water
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customevaporated
9. customto afford the product