Triethylamine → HCID 19856070, compound

HRID 564057Notes

Reaction equation

HRID 564057 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH2:10][CH2:11][OH:12])=[CH:8][CH:9]=1)=[O:4].C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH2:10][CH2:11][O:12][S:21]([CH3:20])(=[O:23])=[O:22])=[CH:8][CH:9]=1)=[O:4]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 10845237Methyl 5-(2-hydroxyethyl)thiophene-2-carboxylate

Product 1

HCID 19856070HCID 19856070, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 300 mg (1.61 mmol) 5-(2-hydroxy-ethyl)-thiophene-2-carboxylic acid methyl ester in 10 mL DCM is added 0.90 mL triethylamine (6.44 mmol) and subsequently 312 μL (4.03 mmol) methanesulfonyl chloride at RT. The reaction mixture is stirred 1 h at RT and is diluted with 50 mL DCM. The organic phase is separated, washed three times with water and is dried over MgSO4. After filtration and evaporation of the solvent, the product is afforded.

Workup

  1. customThe organic phase is separated
  2. washwashed three times with water
  3. dry with materialis dried over MgSO4
  4. filtrationAfter filtration and evaporation of the solvent
  5. customthe product is afforded

Sources & evidence

ORD record
ord-5416704cc0124635a637a8a30876b667
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

Loading…