反应详情

To 7.00 g (46.6 mmol) 1-(4-hydroxymethyl-phenyl)-ethanone in 100 mL THF is added 22.5 g (46.6 mmol) tetrabutylammonium-tribromide dissolved in MeOH/THF. The reaction mixture is stirred 1 h at RT and the solvent is evaporated. The residue is dissolved with water and tertbutylmethylether. The organic phase is washed eight times with water. The combined organic phase is dried over MgSO4, filtered and the solvent is evaporated. The residue is elutriated with diisopropylether and the precipitate is collected and dried.

1. customthe solvent is evaporated
2. dissolutionThe residue is dissolved with water and tertbutylmethylether
3. washThe organic phase is washed eight times with water
4. dry with materialThe combined organic phase is dried over MgSO4
5. filtrationfiltered
6. customthe solvent is evaporated
7. customthe precipitate is collected
8. customdried