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1-(4-(Hydroxymethyl)phenyl)ethanone → 2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-(Hydroxymethyl)phenyl)ethanone | HCID 585264 | — |
| 反応物 | Tetra-n-butylammonium tribromide | HCID 23500184 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 生成物 | 2-Bromo-1-[4-(hydroxymethyl)phenyl]ethanone | HCID 19798053 | — |
反応手順
To 7.00 g (46.6 mmol) 1-(4-hydroxymethyl-phenyl)-ethanone in 100 mL THF is added 22.5 g (46.6 mmol) tetrabutylammonium-tribromide dissolved in MeOH/THF. The reaction mixture is stirred 1 h at RT and the solvent is evaporated. The residue is dissolved with water and tertbutylmethylether. The organic phase is washed eight times with water. The combined organic phase is dried over MgSO4, filtered and the solvent is evaporated. The residue is elutriated with diisopropylether and the precipitate is collected and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067590B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-8fab9a1e59cc4af5bde38fab9d368b85 |
| 出典メモ | uspto-grants-2011_11 |