HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → 1-[2-(4-Bromomethyl-phenyl)-ethyl]-4-(pyridin-2-ylmethoxy)-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 1-[2-(4-hydroxymethylphenyl)-ethyl]-4-(pyridin-2-ylmethoxy)-1H-pyridin-2-one | HCID 67006693 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 1-[2-(4-Bromomethyl-phenyl)-ethyl]-4-(pyridin-2-ylmethoxy)-1H-pyridin-2-one | HCID 67007740 | — |
Reaction Steps
To 1.20 g (3.57 mmol) 1-[2-(4-hydroxymethyl-phenyl)-ethyl]-4-(pyridin-2-ylmethoxy)-1H-pyridin-2-one (example 3.1a) in 25 mL of DCM is added at 0° C. 0.24 mL (2.50 mmol) phosphorus tribromide. After warming to RT, the mixture is stirred 2 h at RT and is diluted with 30 mL tertbutylmethylether. The precipitate is collected and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067590B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-620830f66267463aa1fd2d7bd7046077 |
| Source note | uspto-grants-2011_11 |