Diisopropylethylamine → N-[1-(4-{2-[4-(2-Fluoro-benzyloxy)-2-oxo-2H-pyridin-1-yl]-ethyl}-benzyl)-piperidin-4-yl]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	4-Acetamidopiperidine	HCID 1445156	—
Reactant	1-[2-(4-bromomethyl-phenyl)ethyl]-4-(2-fluoro-benzyloxy)-1H-pyridin-2-one	HCID 67006665	—
Product	N-[1-(4-{2-[4-(2-Fluoro-benzyloxy)-2-oxo-2H-pyridin-1-yl]-ethyl}-benzyl)-piperidin-4-yl]-acetamide	HCID 58042701	—

Reaction Steps

N-[1-(4-{2-[4-(2-Fluoro-benzyloxy)-2-oxo-2H-pyridin-1-yl]-ethyl}-benzyl)-piperidin-4-yl]-acetamide is prepared as example 9.1c from 80 mg (0.19 mmol) 1-[2-(4-bromomethyl-phenyl)ethyl]-4-(2-fluoro-benzyloxy)-1H-pyridin-2-one (example 9.1b), 41 mg (0.29 mmol) N-piperidin-4-yl-acetamide and 84 μL (0.48 mmol) N-ethyl-diisopropylamine as base.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08067590B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-4a471112dd8249e0a000844a7a236860
Source note	uspto-grants-2011_11