反应详情

To 240 mg (0.71 mmol) 5-benzyloxy-2-[2-(4-hydroxymethyl-phenyl)-ethyl]-2H-pyridazin-3-one (example 21.1a) in 2.0 mL of DCM is added at 0° C. 134 μL (1.43 mmol) phosphorus tribromide. The mixture is stirred 4 h at RT, cooled to 0° C. and aqueous saturated NaHCO3-solution is added until pH >7. The layers are separated, the aqueous phase is extracted with DCM and the combined organic phase is washed with water, dried over MgSO4, filtered and the solvent is evaporated.

1. temperaturecooled to 0° C.
2. customThe layers are separated
3. extractionthe aqueous phase is extracted with DCM
4. washthe combined organic phase is washed with water
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customthe solvent is evaporated