4-Benzyloxy-2(1H)-pyridone → HCID 86623692, compound

HRID 564203Notes

Reaction equation

HRID 564203 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21](CO)=[CH:20][CH:19]=2)=[O:17])[C:11](=[O:26])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC1C=CNC(=O)C=1)C1C=CC=CC=1.ClCC(C1C=C2C(=CC=1)[CH2:51][N:50]([C:55](=[O:60])[C:56]([F:59])([F:58])[F:57])[CH2:49]2)=O>CS(C)=O>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][C:16](=[O:17])[C:18]2[CH:19]=[C:20]3[C:21](=[CH:22][CH:23]=2)[CH2:51][N:50]([C:55](=[O:60])[C:56]([F:59])([F:58])[F:57])[CH2:49]3)[C:11](=[O:26])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 36077244-Benzyloxy-2(1H)-pyridoneHCID 58042801HCID 58042801, compoundHCID 670068424-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one

Product 1

HCID 86623692HCID 86623692, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

4-Benzyloxy-1-{2-oxo-2-[2-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-isoindol-5-yl]-ethyl}-1H-pyridin-2-one is prepared following preparation 15b from 1.50 g (7.45 mmol) 4-benzyloxy-1H-pyridin-2-one and 2.28 g (7.83 mmol) 1-[5-(2-chloro-acetyl)-1,3-dihydro-isoindol-2-yl]-2,2,2-trifluoro-ethanone (see preparation 23) in DMSO as solvent.

Sources & evidence

ORD record
ord-c5a65ce2b605423887e367d1de48ef89
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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