HCID 58042801, compound → HCID 86623694, compound

HRID 564209Notes

Reaction equation

HRID 564209 reaction equation
C(OC1C=CN(CC(C2C=CC(CO)=CC=2)=O)C(=O)C=1)C1C=CC=CC=1.[CH2:27]([O:34][C:35]1[CH:40]=[N:39][NH:38][C:37](=[O:41])[CH:36]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.Cl[CH2:43][C:44]([C:46]1[CH:47]=[C:48]2[C:52](=[CH:53][CH:54]=1)[CH2:51][N:50]([C:55](=[O:60])[C:56]([F:59])([F:58])[F:57])[CH2:49]2)=[O:45]>CS(C)=O>[CH2:27]([O:34][C:35]1[CH:40]=[N:39][N:38]([CH2:43][C:44](=[O:45])[C:46]2[CH:47]=[C:48]3[C:52](=[CH:53][CH:54]=2)[CH2:51][N:50]([C:55](=[O:60])[C:56]([F:59])([F:57])[F:58])[CH2:49]3)[C:37](=[O:41])[CH:36]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

5

Reactant 3

HCID 58042801HCID 58042801, compoundHCID 598221075-(benzyloxy)pyridazin-3(2H)-oneHCID 670068424-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one

Product 1

HCID 86623694HCID 86623694, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

5-Benzyloxy-2-{2-oxo-2-[2-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-iso indol-5-yl]-ethyl}-2H-pyridazin-3-one is prepared following preparation 15b from 1.38 g (6.80 mmol) 5-benzyloxy-2H-pyridazin-3-one (preparation 5c) and 2.08 g (7.14 mmol) 1-[5-(2-chloro-acetyl)-1,3-dihydroisoindol-2-yl]-2,2,2-trifluoro-ethanone (see preparation 23) in DMSO as solvent (purification via reversed HPLC chromatography).

Workup

  1. custom(purification via reversed HPLC chromatography)

Sources & evidence

ORD record
ord-1da1ca221f24498ea4cab881d7cfd761
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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