HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 4-(4-Fluoro-benzyloxy)-1-{2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 1-[2-(4-chloromethylphenyl)-2-oxo-ethyl]-4-(4-fluoro-benzyloxy)-1H-pyridin-2-one | HCID 58042703 | — |
| Product | 4-(4-Fluoro-benzyloxy)-1-{2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one | HCID 58042758 | — |
Reaction Steps
4-(4-Fluoro-benzyloxy)-1-{2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one is prepared following example 1.1b from 100 mg (0.26 mmol) 1-[2-(4-chloromethylphenyl)-2-oxo-ethyl]-4-(4-fluoro-benzyloxy)-1H-pyridin-2-one (preparation 32.1) and 65 mg (0.65 mmol) N-methylpiperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067590B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-af27e1639587475bb6ea35bd785b2f88 |
| Source note | uspto-grants-2011_11 |