1-Methylpiperazine → 4-(4-Fluoro-benzyloxy)-1-{2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one

HRID 564213Notes

Reaction equation

HRID 564213 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:27])[CH2:10][N:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[CH:13][C:12]2=[O:26])=[CH:5][CH:4]=1.[CH3:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[F:25][C:22]1[CH:23]=[CH:24][C:19]([CH2:18][O:17][C:14]2[CH:15]=[CH:16][N:11]([CH2:10][C:9]([C:6]3[CH:7]=[CH:8][C:3]([CH2:2][N:32]4[CH2:33][CH2:34][N:29]([CH3:28])[CH2:30][CH2:31]4)=[CH:4][CH:5]=3)=[O:27])[C:12](=[O:26])[CH:13]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 580427031-[2-(4-chloromethylphenyl)-2-oxo-ethyl]-4-(4-fluoro-benzyloxy)-1H-pyridin-2-one

Product 1

HCID 580427584-(4-Fluoro-benzyloxy)-1-{2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one

Procedure

4-(4-Fluoro-benzyloxy)-1-{2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one is prepared following example 1.1b from 100 mg (0.26 mmol) 1-[2-(4-chloromethylphenyl)-2-oxo-ethyl]-4-(4-fluoro-benzyloxy)-1H-pyridin-2-one (preparation 32.1) and 65 mg (0.65 mmol) N-methylpiperazine.

Sources & evidence

ORD record
ord-af27e1639587475bb6ea35bd785b2f88
Source dataset
uspto-grants-2011_11
Patent number
US08067590B2

Reaction notes

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