反应详情

The crude product from EXAMPLE 51A in acetic acid (40 ml) was heated to 90° C. for 1.5 hours. After cooling, the suspension was filtered. The filter cake was washed with acetic acid, and stirred in saturated NaHCO3 for 30 minutes. The solid was filtered, washed with water and ether, and dried under vacuum to provide the title compound as an off-white solid. MS (DCI/NH3) m/z: 297.1 (M+H)+.

1. temperatureAfter cooling
2. filtrationthe suspension was filtered
3. washThe filter cake was washed with acetic acid
4. filtrationThe solid was filtered
5. washwashed with water and ether
6. customdried under vacuum