Methyl 6-(2-amino-3-carbamoylphenylcarbamoyl)nicotinate → methyl 6-(4-carbamoyl-1H-benzo[d]imidazol-2-yl)nicotinate

Participants

Reaction Steps

The crude product from EXAMPLE 51A in acetic acid (40 ml) was heated to 90° C. for 1.5 hours. After cooling, the suspension was filtered. The filter cake was washed with acetic acid, and stirred in saturated NaHCO3 for 30 minutes. The solid was filtered, washed with water and ether, and dried under vacuum to provide the title compound as an off-white solid. MS (DCI/NH3) m/z: 297.1 (M+H)+.

Provenance & Evidence