反应详情

1.60 g of (E)-3-[1-(toluene-4-sulfonyl)-1H-pyrrol-3yl]-acrylic acid tert-butyl ester (compound C1) are dissolved in 70 ml of dichloromethane at ambient temperature. Then 7 ml of trifluoroacetic acid (TFA) are added and stirred for 4 hours. The solvent is evaporated to dryness and to the residue are added 30 ml of water. The water phase is extracted exhaustively with ethyl acetate. Then the organic phase is dried over sodium sulfate. The filtrate is evaporated and dried under vacuo to give 0.951 g of the title compound as a pale grey solid.

1. customThe solvent is evaporated to dryness and to the residue
2. additionare added 30 ml of water
3. extractionThe water phase is extracted exhaustively with ethyl acetate
4. dry with materialThen the organic phase is dried over sodium sulfate
5. customThe filtrate is evaporated
6. customdried under vacuo