2,6-Difluoro-3-nitrobenzoic acid → 3-Amino-2,6-difluorobenzoic acid

HRID 564290Notes

Reaction equation

HRID 564290 reaction equation
[F:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[C:7]([F:14])[C:3]=1[C:4]([OH:6])=[O:5].[H][H]>[C].[Pd].CO>[NH2:11][C:10]1[C:2]([F:1])=[C:3]([C:7]([F:14])=[CH:8][CH:9]=1)[C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 3026292,6-Difluoro-3-nitrobenzoic acidHCID 178418361HCID 178418361, compound

Product 1

HCID 184053523-Amino-2,6-difluorobenzoic acidYield 93%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A solution of 2,6-difluoro-3-nitrobenzoic acid and 10% palladium carbon added to 10 ml of methanol was stirred in a hydrogen atmosphere at room temperature for 2 hours. The catalyst was filtered off and then the solvent was removed under a reduced pressure to obtain the desired product (Yield: 93%) as a white solid.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed under a reduced pressure

Sources & evidence

ORD record
ord-3341bca4d0554b49aae95f7eac297a40
Source dataset
uspto-grants-2011_11
Patent number
US08067638B2

Reaction notes

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