HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoro-3-nitrobenzoic acid → 3-Amino-2,6-difluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoro-3-nitrobenzoic acid | HCID 302629 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-2,6-difluorobenzoic acid | HCID 18405352 | 93% |
Reaction Steps
A solution of 2,6-difluoro-3-nitrobenzoic acid and 10% palladium carbon added to 10 ml of methanol was stirred in a hydrogen atmosphere at room temperature for 2 hours. The catalyst was filtered off and then the solvent was removed under a reduced pressure to obtain the desired product (Yield: 93%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067638B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-3341bca4d0554b49aae95f7eac297a40 |
| Source note | uspto-grants-2011_11 |