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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 564376Generated: October 25, 2026

6-Methoxy-3-pyridinylamine → m-(Trifluoromethyl)benzamide

https://huagongshe.com/reaction/564376

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Methoxy-3-pyridinylamineHCID 81121—
ReactantN-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamideHCID 16722463—
Productm-(Trifluoromethyl)benzamideHCID 74535—

Reaction Steps

N-[2-({3R)-1-[1-(3-ethoxyphenyl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide was synthesized in similar fashion to N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide, substituting 3-ethoxyaniline for 6-methoxypyridin-3-amine. The crude product was purified by preparative HPLC. MS m/z: 519 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08067457B2
Source datasetuspto-grants-2011_11
ORD IDord-6cd952fe66ec4153a64a02fbd3677703
Source noteuspto-grants-2011_11