6-Methoxy-3-pyridinylamine → Benzamide

Participants

Role	Name	HCID	Charge
Reactant	6-Methoxy-3-pyridinylamine	HCID 81121	—
Reactant	4-Amino-3,5-dimethylisoxazole	HCID 182040	—
Reactant	N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide	HCID 16722463	—
Product	Benzamide	HCID 2331	—

Reaction Steps

N-[2-({(3R)-1-[1-(3,5-dimethylisoxazol-4-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-trifluoromethyl)benzamide was synthesized in similar fashion to N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide, 3,5-dimethylisoxazol-4-amine was substituted for 6-methoxypyridin-3-amine. The crude product was purified by preparative HPLC. MS m/z: 494 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08067457B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-f54452ff13634a7baafcedb835b4a4d3
Source note	uspto-grants-2011_11