反应详情

N-[2-({(3R)-1-[1-(3,5-dimethylisoxazol-4-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-trifluoromethyl)benzamide was synthesized in similar fashion to N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide, 3,5-dimethylisoxazol-4-amine was substituted for 6-methoxypyridin-3-amine. The crude product was purified by preparative HPLC. MS m/z: 494 (M+1).

1. customThe crude product was purified by preparative HPLC