1-Benzylpiperidin-3-amine → N-(2-oxo-2-(1-(tetrahydro-2H-pyran-4-yl)piperidin-3-ylamino)ethyl)-3-(trifluoromethyl)benzamide

HRID 564417Notes

Reaction equation

HRID 564417 reaction equation
[O:1]=[C:2]([NH:17][CH:18]1[CH2:22][CH2:21][N:20]([CH:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[CH2:19]1)[CH2:3][NH:4][C:5](=[O:16])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1.[CH2:29](N1CCCC(N)C1)C1C=CC=CC=1.C(N1CC[C@@H](N)C1)C1C=CC=CC=1>>[O:1]=[C:2]([NH:17][CH:18]1[CH2:22][CH2:21][CH2:29][N:20]([CH:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[CH2:19]1)[CH2:3][NH:4][C:5](=[O:16])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1

Participants

4

Reactant 3

HCID 4216941-Benzylpiperidin-3-amineHCID 1519354(3R)-1-benzylpyrrolidin-3-amineHCID 67005250N-(2-oxo-2-{[1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl]amino}ethyl)-3-(trifluoromethyl)benzamide

Product 1

HCID 57814104N-(2-oxo-2-(1-(tetrahydro-2H-pyran-4-yl)piperidin-3-ylamino)ethyl)-3-(trifluoromethyl)benzamide

Procedure

The title compound was synthesized in similar fashion to N-(2-oxo-2-{[1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl]amino}ethyl)-3-(trifluoromethyl)benzamide whereby 1-benzylpiperidin-3-amine was substituted for (3R)-1-benzylpyrrolidin-3-amine as was isolated as a white solid.

Workup

  1. customas was isolated as a white solid

Sources & evidence

ORD record
ord-256186d4e5d145228b54be64c9375d29
Source dataset
uspto-grants-2011_11
Patent number
US08067457B2

Reaction notes

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