反应详情

温度

50 °C

To a suspension of 3-bromo-5-(methyloxy)benzoic acid (9.6 g, 41.6 mmol) in toluene (60 mL), thionyl chloride (9.89 g, 83.1 mmol) and DMF (0.10 mL) were added and stirred at 50° C. for 4 h. The reaction was allowed to cooled to room temperature, and then the excess thionyl chloride was removed in vacuo. The residue was dissolved in toluene (50 mL) and the mixture was added to a solution of ammonia (25%, 50 mL). A precipitate formed and was filtered off using Celite, and dried, to afford 3-bromo-5-(methyloxy)benzamide (8.70 g, 90%).

1. additionwere added
2. temperatureto cooled to room temperature
3. customthe excess thionyl chloride was removed in vacuo
4. dissolutionThe residue was dissolved in toluene (50 mL)
5. additionthe mixture was added to a solution of ammonia (25%, 50 mL)
6. customA precipitate formed
7. filtrationwas filtered off
8. customdried