Toluene → 3-Bromo-4-chlorobenzamide

HRID 564498Notes

Reaction equation

HRID 564498 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5](O)=[O:6].C(Cl)(=O)C(Cl)=O.C[N:19](C=O)C.C1(C)C=CC=CC=1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5]([NH2:19])=[O:6]

Participants

6

Reactant 4

HCID 1140TolueneHCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27355443-Bromo-4-chlorobenzoic acid

Product 1

HCID 532166633-Bromo-4-chlorobenzamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Bromo-4-chlorobenzoic acid (2.35 g, 10 mmol) was suspended in CH2Cl2 (50 mL) and stirred under argon at room temperature. Oxalyl chloride (2.53 g, 20 mmol) was added followed by DMF (10 μL). Gas evolution began, and the mixture was stirred until gas evolution ceased. The solvents were pumped off and toluene was added and stripped off to remove excess oxalyl chloride. The residue was taken up in EtOAc and added to concentrated ammonium hydroxide (10 mL). This was stirred for thirty min. The phases were separated and the organic washed 1× with brine, dried over anhydrous Na2SO4, filtered, and concentrated. The residue was crystallized from EtOAc/hexane to give the title compound as a white crystalline solid. LC-MS m/z 233.7 (M+H)+, 1.54 min (ret time); mp 146-147° C.; analytical HPLC shows 100% purity, (ret time 11.835 min).

Workup

  1. stirringthe mixture was stirred until gas evolution
  2. customto remove excess oxalyl chloride
  3. additionadded to concentrated ammonium hydroxide (10 mL)
  4. stirringThis was stirred for thirty min
  5. customThe phases were separated
  6. washthe organic washed 1× with brine
  7. dry with materialdried over anhydrous Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated
  10. customThe residue was crystallized from EtOAc/hexane

Sources & evidence

ORD record
ord-01c311ea49864740973c30fb5ff9c510
Source dataset
uspto-grants-2011_11
Patent number
US08067408B2

Reaction notes

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