反应详情

A solution of 6-bromo-8-chloroquinazolin-2-ol (9.0 g, 35 mmol) in phosphorus oxychloride (100 mL) was refluxed for 5 hours. Most of phosphorus oxychloride was removed under reduced pressure, and the residue was added to a stirring ice water (500 mL). The resulting precipitate was collected via filtration and then refluxed in THF. The solid was filtered off, and the filtrate was concentrated to give the title compound a yellow solid (7.0 g, 78%). MS (ES+) C8H4BrClN2 requires: 275, 277, found: 276, 278 [M+H]+.

1. customMost of phosphorus oxychloride was removed under reduced pressure
2. additionthe residue was added to a stirring ice water (500 mL)
3. filtrationThe resulting precipitate was collected via filtration
4. temperaturerefluxed in THF
5. filtrationThe solid was filtered off
6. concentrationthe filtrate was concentrated