反应详情

A solution of 6-bromo-7-chloroquinazolin-2-ol (6.0 g, 23 mmol) in phosphorus oxychloride (50 mL) was refluxed for 5 hours. The reaction was cooled to room temperature, and most of phosphorus oxychloride was removed under reduced pressure. The residue was dropwise added to ice water (500 mL), and the resulting precipitate was collected by the filtration to give the title compound as a yellow solid (3 g, 48%).

1. custommost of phosphorus oxychloride was removed under reduced pressure
2. additionThe residue was dropwise added to ice water (500 mL)
3. filtrationthe resulting precipitate was collected by the filtration