Phosphorus oxychloride → 6-Bromo-2,7-dichloroquinazoline

HRID 56457Notes

Reaction equation

HRID 56457 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[C:7](O)[N:6]=[CH:5]2.P(Cl)(Cl)([Cl:16])=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[C:7]([Cl:16])[N:6]=[CH:5]2

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178517413HCID 178517413, compound

Product 1

HCID 593252636-Bromo-2,7-dichloroquinazolineYield 48%

Procedure

A solution of 6-bromo-7-chloroquinazolin-2-ol (6.0 g, 23 mmol) in phosphorus oxychloride (50 mL) was refluxed for 5 hours. The reaction was cooled to room temperature, and most of phosphorus oxychloride was removed under reduced pressure. The residue was dropwise added to ice water (500 mL), and the resulting precipitate was collected by the filtration to give the title compound as a yellow solid (3 g, 48%).

Workup

  1. custommost of phosphorus oxychloride was removed under reduced pressure
  2. additionThe residue was dropwise added to ice water (500 mL)
  3. filtrationthe resulting precipitate was collected by the filtration

Sources & evidence

ORD record
ord-f3deed176f1046089284ac2a612c26f2
Source dataset
uspto-grants-2016_09
Patent number
US09434700B2

Reaction notes

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