反应详情

A solution of 6-H-furo[2,3-c]pyridin-7-one (1.0 g) in phosphorous oxychloride (10 ml) was stirred at 110° C. for 30 minutes under dry nitrogen. The mixture was cooled, poured onto ice/water (50 ml) and basified to pH10 with 2N sodium hydroxide solution. The mixture was extracted with ether (3×50 ml), the combined extracts dried over sodium sulfate and filtered. Removal of the solvent in vacuo gave the title compound (1.0 g) as a white solid.

1. temperatureThe mixture was cooled
2. additionpoured onto ice/water (50 ml)
3. extractionThe mixture was extracted with ether (3×50 ml)
4. dry with materialthe combined extracts dried over sodium sulfate
5. filtrationfiltered
6. customRemoval of the solvent in vacuo