Iodoethane → 2-Ethyl-7-methoxyfuro[2,3-c]pyridine

HRID 564713Notes

Reaction equation

HRID 564713 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[CH:10][O:9][C:8]=12.[CH2:12](I)[CH3:13]>>[CH2:12]([C:10]1[O:9][C:8]2=[C:3]([O:2][CH3:1])[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=1)[CH3:13]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 105829307-Methoxyfuro[2,3-C]pyridine

Product 1

HCID 221127792-Ethyl-7-methoxyfuro[2,3-c]pyridine

Procedure

Starting from 7-methoxyfuro[2,3-c]pyridine (4.5 g) and ethyl iodide (4.0 ml). Purification by column chromatography on silica eluting with 70% hexane in ethyl acetate gave the title compound (30 g) as a colourless oil.

Workup

  1. customPurification by column chromatography on silica eluting with 70% hexane in ethyl acetate

Sources & evidence

ORD record
ord-f4fbf4a9a57b411181f245739bdd4a89
Source dataset
uspto-grants-2001_01
Patent number
US06169090A

Reaction notes

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