Boron Trichloride → HCID 178491549, compound

HRID 564745Notes

Reaction equation

HRID 564745 reaction equation
C[O:2][C:3]1[N:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:4]=1[CH:5]=[O:6].B(Cl)(Cl)Cl>C(Cl)Cl>[OH:2][C:3]1[N:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:4]=1[CH:5]=[O:6]

Participants

4

Reactant 2

HCID 25135Boron TrichlorideHCID 122692112,6-Dimethoxypyridine-3-carbaldehyde

Product 1

HCID 178491549HCID 178491549, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

8.4 g (0.05 mol) 2,6-dimethoxy-nicotinaldehyde was solved in 75 ml methylene chloride. At 0° C. (0.2 mol) BCl3 as 1 molar solution in methylene chloride 200 ml was added and stirred at room temperature for 20 h. The mixture was poured on ice/water, neutralized and extracted with CH2Cl2. Evaporation of the solvent affords 5.7 g (75%) of the title compound.

Workup

  1. additionThe mixture was poured on ice/water
  2. extractionextracted with CH2Cl2
  3. customEvaporation of the solvent

Sources & evidence

ORD record
ord-dc92bb21c0f641ae8fa61c5407a06367
Source dataset
uspto-grants-2001_01
Patent number
US06169092A

Reaction notes

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