反应详情

8.4 g (0.05 mol) 2,6-dimethoxy-nicotinaldehyde was solved in 75 ml methylene chloride. At 0° C. (0.2 mol) BCl3 as 1 molar solution in methylene chloride 200 ml was added and stirred at room temperature for 20 h. The mixture was poured on ice/water, neutralized and extracted with CH2Cl2. Evaporation of the solvent affords 5.7 g (75%) of the title compound.

1. additionThe mixture was poured on ice/water
2. extractionextracted with CH2Cl2
3. customEvaporation of the solvent