1-Methyl-2-(tributylstannyl)-1H-imidazole → HCID 22112889, compound

HRID 564762Notes

Reaction equation

HRID 564762 reaction equation
[CH2:1]([O:8][C:9]1[CH:26]=[CH:25][C:12]([NH:13][C:14]2[C:15]3[CH:23]=[C:22](Cl)[N:21]=[CH:20][C:16]=3[N:17]=[CH:18][N:19]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[C:32]1[N:33]([CH3:37])[CH:34]=[CH:35][N:36]=1)CCC>>[CH2:1]([O:8][C:9]1[CH:26]=[CH:25][C:12]([NH:13][C:14]2[C:15]3[CH:23]=[C:22]([C:32]4[N:33]([CH3:37])[CH:34]=[CH:35][N:36]=4)[N:21]=[CH:20][C:16]=3[N:17]=[CH:18][N:19]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27632521-Methyl-2-(tributylstannyl)-1H-imidazoleHCID 219521684-(4-Benzyloxyanilino)6-chloropyrido[3,4-d]pyrimidine

Product 1

HCID 22112889HCID 22112889, compound

Procedure

Prepared according to Procedure B from 4-(4-benzyloxyanilino)-6-chloropyrido[3,4-d]pyrimidine and 2-(tri-n-butylstannyl)-N-methylimidazole (prepared according to the published method: J. Organometallic Chem., (1989), 61); δH [2H6]-DMSO 10.35 (1H,s), 9.17 (1H,s), 9.13 (1H,s), 8.65 (1H, s), 7.79 (2H,d), 7.32-7.55 (6H,m), 7.13 (1H,s), 7.09 (2H,d), 5.16 (2H,s), 4.10 (3H,s); m/z (M+1)+409.

Workup

  1. customPrepared
  2. customprepared

Sources & evidence

ORD record
ord-b6e1153ffc0d4d9c9ecae39b190bdb68
Source dataset
uspto-grants-2001_01
Patent number
US06169091A

Reaction notes

Loading…