Aniline, p-(phenylthio)- (6CI,7CI,8CI) → 6-Chloro-4-(4-phenylthioanilino)pyrido[3,4-d]pyrimidine hydochloride

HRID 564770Notes

Reaction equation

HRID 564770 reaction equation
[C:1]1([S:7][C:8]2[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:15][N:16]1[C:21]2[CH:22]=[N:23][C:24]([Cl:26])=[CH:25][C:20]=2[CH:19]=[N:18][CH2:17]1>>[ClH:15].[Cl:26][C:24]1[N:23]=[CH:22][C:21]2[N:16]=[CH:17][N:18]=[C:19]([NH:12][C:11]3[CH:13]=[CH:14][C:8]([S:7][C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)=[CH:9][CH:10]=3)[C:20]=2[CH:25]=1

Participants

3

Reactant 2

HCID 96081Aniline, p-(phenylthio)- (6CI,7CI,8CI)HCID 867561911,6-Dichloropyrido[3,4-d]pyrimidine

Product 1

HCID 882170046-Chloro-4-(4-phenylthioanilino)pyrido[3,4-d]pyrimidine hydochloride

Procedure

Prepared according to Procedure A from 4-(phenylthio)aniline (commercially available from Salor) and 1,6-dichloropyrido[3,4-d]pyrimidine; δH [2H6]-DMSO 8.94 (1H,s), 8.85 (1H,s), 8.25 (1H,s), 7.96 (2H,d), 7.24-7.49 (7H,m); m/z (M+1)+365.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-50d0935d4cd747fb86015b40fcb6fb20
Source dataset
uspto-grants-2001_01
Patent number
US06169091A

Reaction notes

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