1-Methylpiperazine → HCID 22112876, compound

HRID 564773Notes

Reaction equation

Cl[C:2]1[N:27]=[CH:26][C:5]2[N:6]=[CH:7][N:8]=[C:9]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([S:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)(=[O:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[CH3:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[CH3:28][N:29]1[CH2:34][CH2:33][N:32]([C:2]2[N:27]=[CH:26][C:5]3[N:6]=[CH:7][N:8]=[C:9]([NH:10][C:11]4[CH:16]=[CH:15][C:14]([S:17]([C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=5)(=[O:19])=[O:18])=[CH:13][CH:12]=4)[C:4]=3[CH:3]=2)[CH2:31][CH2:30]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 219521656-Chloro-4-(4-phenylsulphonylanilino)pyrido[3,4-d]pyrimidine

Product 1

HCID 22112876HCID 22112876, compound

Procedure

Prepared according to Procedure C from 6-chloro-4-(4-phenylsulphonylanilino)pyrido[3,4-d]pyrimidine and 1-methylpiperazine; δH (CDCl3+DMSO) 9.66 (1H,s), 8.91 (1H,s), 8.52 (1H,s), 8.15 (2H, d), 7.88-7.98 (4H,m), 7.48-7.62 (4H,m), 3.66-3.74 (4H,m), 2.52-2.64 (4H,m), 2.38 (3H,s); m/z (M+1)+461.

Workup

customPrepared

Sources & evidence

ORD record: ord-be25429512934ebd99a04a325178eff3
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06169091A

Reaction notes

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