反应详情

A solution of 6-bromo-5-fluoroquinazolin-2-ol (3.0 g, 12.34 mmol) in phosphoryl trichloride (10 mL) was refluxed at 135° C. for 5 hours. Most of phosphoryl trichloride was removed under reduced pressure, and the residue was dropwise added to ice water (200 mL). The resulting precipitate was collected via filtration as a yellow solid (3.1 g, 96%). MS (ES+) C8H3BrClFN2 requires: 260, found: 261, 263 [M+H]+.

1. customMost of phosphoryl trichloride was removed under reduced pressure
2. additionthe residue was dropwise added to ice water (200 mL)
3. filtrationThe resulting precipitate was collected via filtration as a yellow solid (3.1 g, 96%)