反应详情

4-Chlorothieno[3,2-d]pyrimidine (0.102 g, 0.60 mmol) and 4-(2-thienylmethoxy)-aniline (prepared according to the published method: WO 96/09294) (0.135 g, 0.66 mmol) were reacted in 2-propanol (5 ml) for 2 hours, according to Procedure A. The product was obtained as a grey-green solid (0.138 g, 61%) with m.p. 181-182° C.; (Found: C, 53.64; H, 3.61; N, 11.04. C17H13N3OS2.HCl.0.25H2O requires: C, 53.68; H, 3.84; N, 11.05%); δH [2H6]-DMSO 11.28 (1H, br s, NH), 8.75 (1H, s, 2-H), 8.45 (1H, d, J 7, 6 H or 7 H) 7.45-7.68 (4H, m, 6H or 7H, 2′-H, 6′-H, 5″-H), 6.95-7.28 (4H, m, 3′-H, 5′-H, 3″-H, 4″-H), 5.32 (2H, s, CH2); m/z 339 (M+).