反应详情

4-Chloro-7-methylthieno[3,2-d]pyrimidine (commercially available from Maybridge Chemical Co. Ltd.) (0.185 g, 1.00 mmol) and 4-phenoxyaniline (0.210 g, 1.1 mmol) were reacted in 2-propanol (5 ml) for 2 hours according to Procedure A. The product was obtained as a yellow solid (0.294 g, 80%), m.p. 243-245° C.; (Found: C, 61.46; H, 4.27, N, 11.32. C19H15N3OS.HCl requires: C, 61.70; H, 4.36; N, 11.36%); δH [2H6]-DMSO 10.85 (1H, br s, NH), 8.78 (1H, s, 2-H), 8.05 (1H, 2, 6-H), 7.69 (2H, d, J 9, 2′-H, 6′-H), 7.42 (2H, t, J 9, 3″-H, 5″-H), 7.00-7.20 (5H, m, 3′-H, 5′-H, 2″-H, 4″-H, 6″-H), 2.43 (3H, s, 7-CH3); m/z (%) 333 (M+).