反应详情

4-Chloro-5-(2-thienyl)thieno[2,3-d]pyrimidine (commercially available from Maybridge Chemical Co. Ltd.) (0.126 g, 0.50 mmol) and 4-phenoxyaniline (0.116 g, 0.63 mmol) were reacted in 2-propanol (3 ml) for 6.5 hours according to Procedure A. The product was obtained as an off-white powder (0.150 g, 71%), m.p. 171-172° C. (effervescence); (Found: C, 62.60; H, 3.60, N, 9.85. C22H15N3OS2.0.67HCl requires: C, 62.06; H, 3.71; N, 9.87%); δH [2H6]-DMSO 8.58 (1H,s), 7.79-7.85 (2H,m), 7.29-7.56 (7H,m), 6.93-7.13 (5H,m); m/z 401 (M+).