Ammonia → 4-(4-Benzyloxy-3-chloroanilino)-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine hydrochloride

HRID 564794Notes

Reaction equation

HRID 564794 reaction equation
[Cl:1][C:2]1[C:3]2[CH:11]=[C:10]([N:12]([CH3:14])[CH3:13])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH2:15]([O:22][C:23]1[CH:29]=[CH:28][C:26]([NH2:27])=[CH:25][C:24]=1[Cl:30])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.ClCCl.N>C(O)C>[ClH:1].[CH2:15]([O:22][C:23]1[CH:29]=[CH:28][C:26]([NH:27][C:2]2[C:3]3[CH:11]=[C:10]([N:12]([CH3:14])[CH3:13])[N:9]=[CH:8][C:4]=3[N:5]=[CH:6][N:7]=2)=[CH:25][C:24]=1[Cl:30])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 6344DichloromethaneHCID 12682854-Benzyloxy-3-chloroanilineHCID 227274534-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine

Product 1

HCID 221128844-(4-Benzyloxy-3-chloroanilino)-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared according to Procedure A from 4-chloro-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine and 4-benzyloxy-3-chloroaniline (prepared according to the published method: WO96/09294); tlc (dichloromethane:ethanol:aq. ammonia, 100:8:1) Rf 0.48; m/z (M+1)+406.

Workup

  1. customPrepared
  2. customprepared

Sources & evidence

ORD record
ord-3ca1b7b17a49492ea5d300f5f0cda9a6
Source dataset
uspto-grants-2001_01
Patent number
US06169091A

Reaction notes

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