HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-(4-Benzyloxy-3-chloroanilino)-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 4-Benzyloxy-3-chloroaniline | HCID 1268285 | — |
| Reactant | 4-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine | HCID 22727453 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Benzyloxy-3-chloroanilino)-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine hydrochloride | HCID 22112884 | — |
Reaction Steps
Prepared according to Procedure A from 4-chloro-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine and 4-benzyloxy-3-chloroaniline (prepared according to the published method: WO96/09294); tlc (dichloromethane:ethanol:aq. ammonia, 100:8:1) Rf 0.48; m/z (M+1)+406.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06169091A |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-3ca1b7b17a49492ea5d300f5f0cda9a6 |
| Source note | uspto-grants-2001_01 |