Ammonia → 6-(N,N-Dimethylamino)-4-[4-(1-phenyl-1-cyanomethyl)anilino]pyrido[3,4-d]pyrimidine hydrochloride

HRID 564795Notes

Reaction equation

HRID 564795 reaction equation
[Cl:1][C:2]1[C:3]2[CH:11]=[C:10]([N:12]([CH3:14])[CH3:13])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:23]#[N:24])=[CH:18][CH:17]=1.ClCCl.N>C(O)C>[ClH:1].[CH3:13][N:12]([C:10]1[N:9]=[CH:8][C:4]2[N:5]=[CH:6][N:7]=[C:2]([NH:15][C:16]3[CH:17]=[CH:18][C:19]([CH:22]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[C:23]#[N:24])=[CH:20][CH:21]=3)[C:3]=2[CH:11]=1)[CH3:14]

Participants

6

Reactant 4

HCID 222AmmoniaHCID 6344DichloromethaneHCID 1167712-(4-Aminophenyl)-2-phenylacetonitrileHCID 227274534-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine

Product 1

HCID 221128906-(N,N-Dimethylamino)-4-[4-(1-phenyl-1-cyanomethyl)anilino]pyrido[3,4-d]pyrimidine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared according to Procedure A from 4-chloro-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine and (4-aminophenyl)-phenylacetonitrile (commercially available from Salor); tlc (dichloromethane:ethanol:aq.ammonia, 100:8:1) Rf 0.43; m/z (M+1)+381.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ec525adb89f34c299045ec78d7c720e1
Source dataset
uspto-grants-2001_01
Patent number
US06169091A

Reaction notes

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